Protein and Cell Biology

Being integrated into the Proteomics and Mass Spectrometry Core Facility, our research focuses on the study of system-wide protein regulation using (mostly, but not exclusively) mass spectrometry-based technology. We are about to refine a LC-MS/MS based method for the characterization of circulating extracellular vesicles from human plasma. On the same line, we are going to establish a immunopeptidomics/proteogenomics pipeline in order to identify antigenic peptides presented on the MHC-I complex. The idea is to offer a comprehensive diagnostic method for biomedical research in the context of leukemia, cancer, cardiovascular and pneumological disease. Our laboratory is furthermore equipped with a cone-and-plate apparatus setup on which adherent cells, e.g. endothelial cells, can be subjected to defined shear stress of different quality. The idea is to study in-vitro the molecular processes of endothelial biology induced by a variety of stimuli under near physiological conditions.